NFHC Member- Dr. Peter Mannon Spotlight Video

July 22nd, 2022

We want you to get to know more about NFHC!  Stay tuned as we provide short videos of our PIs and students.  Get to know their lab, what they study, and how they complete their work.

Our faculty spotlight for July is Dr. Peter Mannon!

Dr. Mannon's translational research in IBD has focused on improving current treatment responses by studying endophenotypes of disease to predict efficacy of approaches and testing novel, or re-purposing existing, drugs for inflammatory bowel disease (IBD). An overarching point of reference for his research program is the gap between response and non-response to conventional and experimental treatments. This perspective has allowed Dr. Mannon and his collaborators to show how IL-10 production and infiltration of the lamina propria with suppressor-inducing plasmacytoid dendritic cells conferred clinical response from G-CSF therapy in Crohn’s disease (while non-responders showed neither finding) and also how high IL-17 production could prevent (predict) lack of clinical response to interferon-beta in ulcerative colitis (UC). Current research projects are focused on defining endophenotypes of IBD that can predict enhanced responses to highly targeted therapeutic agents, specifically anti-IL-13, anti-IL-17, and anti-TNFa in treating UC as well as identifying the microbial-antigen reactivity of highly shared TCRβ CDR3 clonotypes in Crohn’s disease which has become the basis for a long-term project to develop T cell-based immunotherapies for Crohn’s disease.