Guha to continue studying inflammation, metabolic diseases

August 9th, 2022

Doctoral student Snigdha Guha made a home for herself in Lincoln while studying cardiovascular disease prevention.

Guha studies pure and isolated gamma glutamyl peptides derived from food as potential preventative measures for vascular inflammation. Vascular inflammation commonly leads to cardiovascular disease, the number one cause of death worldwide.

“We are trying to find dietary interventions that can be used to prevent or reduce the number of people who reach that extreme stage where they’re taking pharmaceuticals with strong side effects or expensive procedures,” she said.

The peptides have shown positive effects both in vitro and in vivo. In a mouse model of atherosclerosis, the peptide showed reduction in plaque formation and lipid accumulation in the aortas of the mice.

These peptides are naturally present in foods such as beans, onion and cheese. The peptides are present in low quantities, requiring extraction methods to concentrate the peptides for use in a pill or enriched food.

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Story by Kateri Hartman | University Communication and Marketing