- Associate Professor, University of Nebraska Medical Center
The Byrareddy lab research activities include understanding of host-virus dynamics, pathogenesis and prevention strategies of Human/Simian Immunodeficiency viruses (HIV/SIV) and other infectious diseases in general using Non-Human Primate models. We recently showed that by blocking of α4β7 integrin, using an antibody against α4β7 (a gut homing molecule) provided sustain virological control in SIV macaque models, emphasizing an importance of gut hemostasis in controlling infection. Current research includes evaluating connection of microbiome-gut-brain axis to understand host immune homeostasis and developing therapeutics for gut-brain disorders.
Routhu NK and Byrareddy SN. Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis. J Neuroimmune Pharmacol. 2017 Jun; 12(2):219-232.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LM, Arnold KB, Woody CW, Walter L, Roos C, Noll A, Ryk DY, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AF, Ansari AA. Sustained Virologic Control in SIV+ Macaques after antiretrovial and α4β7 antibody therapy. Science. 2016 Oct 14; 354(6309): 197-202
Byrareddy SN, Sidell N, Zhao C, Dunbar P, Little D, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Arthos J, Cicala C, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA. Species-Specific Differences in the Expression and Regulation of Alpha 4 Beta7 (α4β7) integrin in Various Non Human Primates. J Immunol. 2015 Jun 15;194(12):5968-79
Santangelo PJ, Rogers KA, Zurla C, Gumber S, Strait K, Conner-Stroud F, Schister DM, Amancha PK, Hong JJ, Byrareddy SN, Hoxie JA, Vidakovic B, Ansari AA, Hunter E, Villinger F. Whole body ImmunoPET reveals active viral reservoirs in SIV infected ART-treated aviremic macaques and elite controllers. Nat Methods. 2015 May;12(5):427-32
Byrareddy SN, Kallam B, Arthos J, Cicala C, Kersh E, McNicholl JM, Hanson D, Reimann K, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo P, Villinger F, Fauci AS, Ansari AA. Targeting α4β7 integrin reduces mucosal transmission of SIV and protects GALT from infection. Nat Med. 2014 Dec;20(12):1397-400.