- Professor, Department of Genetics, Cell Biology and Anatomy at the University of Nebraska Medical Center
The Norgren lab is focused on applying genomics to nonhuman primate models of human disease. The lab has developed a number of key resources necessary for nonhuman primate research including a Rhesus Macaque Genome Array (in collaboration with Affymetrix) for gene expression studies and a new rhesus macaque genome assembly and annotation which is widely used for NextGen sequencing studies with this species. In collaboration with the Byrareddy lab, we are looking at the interaction of the microbiome with rhesus macaques in health and disease. Rhesus macaques are important animal models for the study of vaccines and therapeutics for infectious diseases such as HIV.
Cornish AS, Gibbs RM, Norgren RB Jr. Exome screening to identify loss-of-function mutations in the rhesus macaque for development of preclinical models of human disease. BMC Genomics. 2016 Mar 2;17:170. doi: 10.1186/s12864-016-2509-5. PubMed PMID: 26935327; PubMed Central PMCID:PMC4776415.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Marçais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Biol Direct. 2014 Oct 14;9(1):20. doi: 10.1186/1745-6150-9-20. PubMed PMID: 25319552; PubMed Central PMCID: PMC4214606.
Maudhoo MD, Ren D, Gradnigo JS, Gibbs RM, Lubker AC, Moriyama EN, French JA, Norgren RB Jr. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Gigascience. 2014 Sep 19;3:14. doi: 10.1186/2047-217X-3-14. eCollection 2014. PubMed PMID: 25243066; PubMed Central PMCID: PMC4169894.
Zhang X, Goodsell J, Norgren RB Jr. Limitations of the rhesus macaque draft genome assembly and annotation. BMC Genomics. 2012 May 30;13:206. doi: 10.1186/1471-2164-13-206. PubMed PMID: 22646658; PubMed Central PMCID:PMC3426473.
Spindel ER, Pauley MA, Jia Y, Gravett C, Thompson SL, Boyle NF, Ojeda SR, Norgren RB Jr. Leveraging human genomic information to identify nonhuman primate sequences for expression array development. BMC Genomics. 2005 Nov 15;6:160. PubMed PMID: 16288651; PubMed Central PMCID: PMC1314899.