Jacques Izard

Jacques Izard portrait

As the health status of the population is getting more complex, the Izard laboratory focuses on the interaction of our microbiome with diet and how this interaction impacts wellness. We use culture-dependent and culture-independent methods to understand the impact of the digestive tract bacteria in health and disease such as cancer. The multi-disciplinary approach aims to obtain a greater understanding of our microbiome function to empower everyone to nurture a supportive microbiome. Our participation in the Nebraska Food for Health Center includes the facilitation of clinical studies centered on food, diet, microbiome and host phenotypes.

Jacques Izard, Ph.D. has been involved in basic science studies focusing on bacteria, biofilms as well as in cohort studies. Those cohort studies includes the Human Microbiome Project (HMP; this project recruited few hundred individuals lacking pro-inflammatory condition to observe the microbiome associated with health), the Health Professionals Follow-Up Study (HPFS; with over 50,000 enrolled volunteers, the purpose is to evaluate hypotheses relating to nutritional factors on the incidence of serious illnesses, such as cancer), and the European Prospective Investigation into Cancer and Nutrition (EPIC; more than half a million participants recruited in a study designed to investigate the relationships between diet, nutritional status, lifestyle and environmental factors, and the incidence of cancer and other chronic diseases). 

Featured Publications

David A. Drew*, Paul Lochhead*, Galeb Abu-Ali, Andrew T. Chan, Curtis Huttenhower, and Jacques Izard. Fecal microbiome in epidemiologic studies – Letter. 2016. Cancer Epidemiology, Biomarkers and Prevention. 25:869.

Jacques Izard and Maria C. Rivera, Editors. 2015. Metagenomics for Microbiology. Elsevier/Academic Press. Print Book ISBN 9780124104723. ebook ISBN: 9780124105089. 

Eric A. Franzosa, Xochitl C. Morgan, Nicola Segata, Levi Waldron, Joshua Reyes, Ashlee M. Earl, Georgia Giannoukos, Matthew Boylan, Dawn Ciulla, Dirk Gevers, Jacques Izard, Wendy S. Garrett, Andrew T. Chan, and Curtis Huttenhower. 2014. Relating the metatranscriptome and metagenome of the human gut. Proceedings of the National Academy of Sciences of the United States of America. 111(22):E2329-E2338.        

Dominique S. Michaud*, Jacques Izard*, Charlotte S. Wilhelm-Benartzi, Doo-Ho You, Verena A Grote, Anne Tjønneland, Christine C. Dahm, Kim Overvad, Mazda Jenab, Veronika Fedirko, Marie Christine, Boutron-Ruault, Françoise Clavel-Chapelon, Antoine Racine, Rudolf Kaaks, Heiner Boeing, Jana Foerster, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Carlotta Sacerdote, Sabina Sieri, Domenico Palli, Rosario Tumino, Salvatore Panico, Peter Siersema, Petra HM Peeters, Lund Eiliv, Aurelio Barricarte, José-María Huerta, Esther Molina-Montes, Miren Dorronsoro, J. Ramón Quirós, Eric J. Duell, Weimin Ye, Malin Sund, Björn Lindkvist, Dorthe Johansen, Kay-Tee Khaw, Nick Wareham, Ruth C. Travis, Paolo Vineis, H. Bas Bueno-de-Mesquita, and Elio Riboli. 2013. Plasma antibodies to oral bacteria and subsequent risk of pancreatic cancer in a large European prospective cohort study (EPIC). Gut. 62:1764-1770.

Nicola Segata, Susan Kinder Haake, Peter Mannon, Katherine P. Lemon, Dirk Gevers, Levi Waldron, Curtis Huttenhower and Jacques Izard. 2012. Composition of the adult digestive tract microbiome based on seven mouth surfaces, tonsils, throat and stool samples. Genome Biology. 13:R42.