- ASSISTANT PROFESSOR, DEPARTMENT OF INTERNAL MEDICINE; University of Nebraska Medical Center
The research in the Samuelson lab is directed toward understanding the mechanisms by which the intestinal microbiota regulates pulmonary host defense against respiratory pathogens. He is interested in delineating the microbial communities and/or the microbial metabolites that inform immune cell programming and trafficking, pro-inflammatory cytokine production, and epithelial permeability in people who chronically consume alcohol. His lab’s studies aim to define the intestinal microbial constituents that mediate pulmonary host defense against respiratory pathogens.
Samuelson, M.M., Pulis, E.E., Ray, C., Arias, C.R., Samuelson, D.R., Mattson, E.E. et al. 2020. Analysis of the fecal microbiome in Kemp's ridley sea turtles Lepidochelys kempii undergoing rehabilitation. Endangered Species Research 43:121-131. https://doi.org/10.3354/ESR01043
Bailey, K.L., Samuelson, D.R., Wyatt, T.A. Alcohol use disorder: A pre-existing condition for COVID-19? 2021. Alcohol. 90:11-17. https://doi.org/10.1016/j.alcohol.2020.10.003
Ronis, M. J., Mercer, K. E., Shankar, K., Pulliam, C., Pedersen, K., Ingelman-Sundberg, M., Friso, S., Samuelson, D., Del Valle, L., Taylor, C., & Welsh, D. A. 2020. Potential role of gut microbiota, the proto-oncogene PIKE (Agap2) and cytochrome P450 CYP2W1 in promotion of liver cancer by alcoholic and nonalcoholic fatty liver disease and protection by dietary soy protein. Chemico-Biological Interactions, 325, . https://doi.org/10.1016/j.cbi.2020.109131
Samuelson, D. R., Siggins, R. W., Ruan, S., Amedee, A. M., Sun, J., Zhu, Q. K., Marasco, W. A., Taylor, C. M., Luo, M., Welsh, D. A., & Shellito, J. E. 2019. Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis. Alcohol, 80, 33-43. https://doi.org/10.1016/j.alcohol.2018.08.012
Lu, X., Samuelson, D. R., Rasco, B. A., & Konkel, M. E. 2012. Antimicrobial effect of diallyl sulphide on Campylobacter jejuni biofilms. Journal of Antimicrobial Chemotherapy, 67(8), 1915-1926. [dks138]. https://doi.org/10.1093/jac/dks138