Amanda Ramer-Tait

Amanda Ramer-Tait portrait

Research interests in the Ramer-Tait laboratory center on the dynamic interactions between the mucosal immune system and intestinal microbial communities. Current research projects are aimed at understanding how host-microbial interactions in the gastrointestinal tract contribute to the pathogenesis of chronic, inflammatory diseases, including inflammatory bowel diseases and obesity. We are also intensively involved in research concerning the interactions among diet, the gut microbiota, and the immunological and metabolic health of the host. To study these complex relationships in vivo, we employ conventional flora, germ-free, and defined microbial community mouse model systems. We utilize approaches spanning the disciplines of cell biology, microbiology, and immunology to mechanistically interrogate the regulation of gastrointestinal homeostasis and inflammation.

Featured Publications

Clavel T, Gomes-Neto JC, Lagkouvardos I, Ramer-Tait AE. Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes. Immunol Rev. 2017 Sep;279(1):8-22. doi: 10.1111/imr.12578. PubMed PMID: 28856739. 

Perez-Munoz ME, Arrieta MC, Ramer-Tait AE, Walter J. A critical assessment of the "sterile womb" and "in utero colonization" hypotheses: implications for research on the pioneer infant microbiome. Microbiome. 2017 Apr 28;5(1):48. doi: 10.1186/s40168-017-0268-4. PubMed PMID: 28454555; PubMed Central PMCID: PMC5410102.

Gomes-Neto JC, Mantz S, Held K, Sinha R, Segura Munoz RR, Schmaltz R, Benson AK, Walter J, Ramer-Tait AE. A real-time PCR assay for accurate quantification of the individual members of the Altered Schaedler Flora microbiota in gnotobiotic mice. J Microbiol Methods. 2017 Apr;135:52-62. doi: 10.1016/j.mimet.2017.02.003. PubMed PMID: 28189782; PubMed Central PMCID: PMC5365401.

Bindels LB, Segura Munoz RR, Gomes-Neto JC, Mutemberezi V, Martinez I, Salazar N, Cody EA, Quintero-Villegas MI, Kittana H, de Los Reyes-Gavilan CG, Schmaltz RJ, Muccioli GG, Walter J, Ramer-Tait AE. Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome. 2017 Feb 7;5(1):12. doi: 10.1186/s40168-017-0230-5. PubMed PMID: 28166818; PubMed Central PMCID: PMC5294823.

Yang J, Bindels LB, Segura Munoz RR, Martinez I, Walter J, Ramer-Tait AE, Rose DJ. Disparate metabolic responses in mice fed a high-fat diet supplemented with maize-derived non-digestible feruloylated oligo- and polysaccharides are linked to changes in the gut microbiota. PLoS One. 2016 Jan 5;11(1):e0146144. doi: 10.1371/journal.pone.0146144. PubMed PMID: 26731528; PubMed Central PMCID: PMC4701460.

Bindels LB, Walter J, Ramer-Tait AE. Resistant starches for the management of metabolic diseases. Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):559-65. doi: 10.1097/MCO.0000000000000223. PubMed PMID: 26406392; PubMed Central PMCID: PMC4612508.